Immune and immunohistochemical profile of pulmonary involvement in fatal forms of dengue: CD8 lymphocyte expression evaluation

• Grant number: 15/16634-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2015
• End date: October 31, 2016
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Vera Luiza Capelozzi
• Grantee: Paulo Chong I Lin
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The lung is a much compromised organ in severe forms of dengue. It is not entirely clear how the vascular endothelium is affected or what triggers vascular leakage, although direct and indirect mechanisms have been proposed. There are few studies with a large number of laboratory confirmed cases of dengue hemorrhagic form and of dengue with complications which describe the histopathological changes, correlating them with endothelial dysfunction, lymphocyte immunophenotyping, TNF-±, nitric oxide expression, VEGF and tissue apoptosis. This project aims to contribute to the elucidation of pulmonary events related to vascular permeability in dengue hemorrhagic fever compared to cases of dengue with complications.