Cleft lip and palate and the occurrence of parental consanguinity

• Grant number: 16/05237-7
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2016
• End date: June 30, 2017
• Field of knowledge: Health Sciences - Collective Health - Epidemiology
• Principal Investigator: Lucimara Teixeira das Neves
• Grantee: Carolina Maia Silva
• Host Institution: Hospital de Reabilitação de Anomalias Craniofaciais (HRAC). Universidade de São Paulo (USP). Bauru , SP, Brazil

Abstract

Studies carried out in Brazil indicate that 1.5 to 1,000 people have some kind of facial cleft lip, palate, or both. After systematic literature research done for this project, it was found a lack of studies in Brazil that investigates the parental consanguineous marriage in cases of cleft lip and palate. Considering parental consanguinity an important variable to be featured in the family history of diseases that have genetic component in the etiology, as the case of cleft lip and palate, the aim of this project is investigate the prevalence of parental consanguineous marriage between parents of patients with cleft lip and palate. Therefore, will be evaluated 2,500 subjects medical records enrolled in the Hospital for Rehabilitation of Craniofacial Anomalies of the University of São Paulo (HRAC-USP), with the purpose of collect data about the prevalence of parental consanguineous marriage between the parents of individuals with cleft lip and palate, the distribution of types of clefts that occur between cases of consanguineous marriage that are found.

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SILVA, CAROLINA MAIA; PEREIRA, MARIA CAROLINA DE MORAES; QUEIROZ, THAIS BERNARDES DE; NEVES, LUCIMARA TEIXEIRA DAS. Family history in non-syndromic orofacial clefts: Is there a pattern?. ORAL DISEASES, JUN 2021. (16/05237-7)

SILVA, CAROLINA MAIA; DE MORAES PEREIRA, MARIA CAROLINA; DE QUEIROZ, THAIS BERNARDES; DAS NEVES, LUCIMARA TEIXEIRA. Can parental consanguinity be a risk factor for the occurrence of nonsyndromic oral cleft?. EARLY HUMAN DEVELOPMENT, v. 135, n. SI, p. 23-26, AUG 2019. (16/05237-7)

SILVA, CAROLINA MAIA; PEREIRA, MARIA CAROLINA DE MORAES; QUEIROZ, THAIS BERNARDES DE; NEVES, LUCIMARA TEIXEIRA DAS. Family history in non-syndromic orofacial clefts: Is there a pattern?. ORAL DISEASES, v. 28, n. 8, p. 10-pg., 2021-06-29. (16/05237-7)

SILVA, CAROLINA MAIA; DE MORAES PEREIRA, MARIA CAROLINA; DE QUEIROZ, THAIS BERNARDES; DAS NEVES, LUCIMARA TEIXEIRA. Can parental consanguinity be a risk factor for the occurrence of nonsyndromic oral cleft?. EARLY HUMAN DEVELOPMENT, v. 135, p. 4-pg., 2019-08-01. (16/05237-7)