CHARACTERISTICS OF FATIGUE IN EFFORTS WITH LOW MUSCLE GLYCOGEN PERFORMED IN DIFFERENT INTENSITIES: A DOUBLE-BLIND AND RANDOMIZED STUDY

• Grant number: 16/09339-9
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: August 01, 2016
• End date: January 31, 2019
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Marcelo Papoti
• Grantee: Carlos Augusto Kalva Filho
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Frequently during a training program, athletes perform sessions with low muscle glycogen (L-Gly) (e.g. weeks with high loads without recovery time). This condition also occurs in last kilometers of long events, being an intrinsic component of performance in this type of competition. Thus, identifying the contribution of central and peripheral processes for fatigue in efforts L-Gly, enables the development of different strategies to increase exercise tolerance and, consequently, improve performance. However, central and peripheral factors related to fatigue are poorly studied in this condition and the experimental design are not applied using the double-blind strategy, which compromise the results. Thus, the main objective of this project is investigate the contribution of central and peripheral factors for fatigue in efforts with L-Gly, performed at different intensities, ensuring double-blind strategy. For this, 14 participants will perform six sessions of evaluation applied in random order and with double-blind strategy. Each session will consist of an effort to depletion of glycogen, the recovery interval (> 4 hours) and the exhaustive efforts perform at different intensities (i.e. moderate, heavy or severe). At the end of the experiment, participants will have performed two sessions in each intensity domain, one with (1.2 g.Kg-1.h-1) and one without (0.3 g.Kg-1.h- 1) replacement of carbohydrates during the recovery interval. To ensure the placebo situation, the solutions have the same taste and odor. Every 10 min for the efforts in different intensities, blood concentrations of tryptophan and the amounts of muscle glycogen will be determinate. In addition, contribution of central and peripheral factors for fatigue will be determined through Twitch interpolation technique and transcranial magnetic stimulation (TMS). Is important to point out that this project will be pioneer to use these techniques for the determination of central and peripheral processes related to fatigue in efforts with L-Gly.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

KALVA FILHO, Carlos Augusto. Influence of muscle glycogen on the origin of fatigue in different domains of intensity. 2019. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.