Antimalarial activity of synthetic compounds: role of Plasmodium kinase signaling and development of transdermal drug delivery device

• Grant number: 16/18078-4
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: November 01, 2016
• End date: October 31, 2017
• Field of knowledge: Biological Sciences - Biochemistry - Biochemistry of Microorganisms
• Principal Investigator: Célia Regina da Silva Garcia
• Grantee: Kênia Viçoso Gomes Lopes
• Host Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 11/51295-5 - Functional genomics in Plasmodium, AP.TEM

Abstract

The current proposal aims to screen P. falciparum malaria parasites with kinase and GSK libraries inhibitors and investigate their mechanism of action aiming to find compounds with potential for arresting the malaria infection. We will also aim to develop a transdermal delivery device in collaboration with Prof Luiz Catalani at IQ-USP. (AU)