Study of AMPA and NMDA receptors at synapses by super resolution microscopy

• Grant number: 16/20985-0
• Support Opportunities: Scholarships abroad - Research
• Start date: August 01, 2017
• End date: July 31, 2018
• Field of knowledge: Physical Sciences and Mathematics - Physics - Classical Areas of Phenomenology and Applications
• Principal Investigator: Andre Alexandre de Thomaz
• Grantee: Andre Alexandre de Thomaz
• Host Investigator: Paul Ronald Selvin
• Host Institution: Instituto de Física Gleb Wataghin (IFGW). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Institution abroad: University of Illinois at Urbana-Champaign, United States

Abstract

In this project we will study the dynamics of the neurotransmitter receptors upon synaptic plasticity changes. There is a great interest in the study of synaptic plasticity because it is the cellular basis of memory formation. In addition, some neurological disorders are associated with synapse problems like schizophrenia and autism. Techniques that will be used are PALM [Photoactivated Localization Microscopy] and STORM [Stochastic Optical Reconstruction Microscopy], both in live and fixed samples. (AU)