Characterization of neoantigens associated to epithelial-mesenchymal transition as potential immunotherapeutic targets

• Grant number: 16/19307-7
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: January 01, 2017
• End date: November 08, 2020
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Pathology
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Heidge Fukumasu
• Grantee: Pedro Ratto Lisboa Pires
• Host Institution: Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil
• Associated research grant: 14/02493-7 - Mammary tumors of dogs and the cancer stem cell theory: a comparative and translational approach, AP.JP
• Associated scholarship(s): 18/06217-5 - Development of a Canine MHC-I neoantigen prediction model in cancer cells, BE.EP.PD

Abstract

Cancer is one of the diseases that concerns the most in human and veterinary medicine, taking an important role at scientific research. In 2012, more than 14 millions pelople dieded because of different types of cancer and it is expected that this number increses up to 20 millions in 2025. Cancer is responsible for about 50% of death in dogs older than 10 years and mammary neoplasias are the most common, corresponding to 52% of the cases. Veterinary oncology it is still fairly timid when compared to human oncology research, however therapeutic target research focused on veterinary diagnosis and prognosis for cancer has increased on the past few years. Immunotherapy is a therapeutic strategy capable of inducing the immune system to cambat cancer cells. Recent immunotherapy approachs based on neoantigens aim to increase antigenicity of imunotherapeutic vaccines to induce an immune response. This project focuses on neoantigens exhibited by major histocompatibility complex 1 (MHC1) in cancer cells and this study's goal is to determine a methodology to indentify potential immunotherapeuctic targets from detection of neoantigens associated to ephtelia-mesenchymal transition (EMT) process in murine and canine models. The use of these neoantigens as molecular markers implies a greater understanding of cancer biology, allowing improvement to diagnosis, prognosis and therapies for breast cancer in dogs and humans. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SANTOS, MARIANA RODRIGUES; PORFIRIO XAVIER, PEDRO LUIZ; LISBOA PIRES, PEDRO RATTO; ROCHETTI, ARINA LAZARO; ROSIM, DANIELE FERNANDA; SCAGION, GUILHERME PEREIRA; PIRES DE CAMPOS ZUCCARI, DEBORA APARECIDA; MUNIR, MUHAMMAD; FERREIRA, HELENA LAGE; FUKUMASU, HEIDGE. Oncolytic effect of Newcastle disease virus is attributed to interferon regulation in canine mammary cancer cell lines. VETERINARY AND COMPARATIVE ONCOLOGY, v. 19, n. 3, p. 593-601, SEP 2021. (18/06217-5, 19/05778-6, 16/19307-7, 18/06216-9, 14/02493-7)