Standardization of the perturbational complexity index for the study of thalamocortical effective connectivity

• Grant number: 17/03678-9
• Support Opportunities: Scholarships in Brazil - Master
• Start date: April 01, 2017
• End date: March 31, 2019
• Field of knowledge: Engineering - Biomedical Engineering - Medical Engineering
• Principal Investigator: Adenauer Girardi Casali
• Grantee: Renzo Comolatti
• Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Federal de São Paulo (UNIFESP). Campus São José dos Campos. São José dos Campos , SP, Brazil
• Associated research grant: 16/08263-9 - Standardization, validation and characterization of a novel index of brain complexity, AP.JP

Abstract

The recent introduction of the Perturbational Complexity Index, a novel measure of brain complexity, made possible to estimate, in an objetive and non-invasive manner, the capacity of the brain to process information by integrating different cortical nuclei. Despite the great potential of the index in evaluating physiological, pharmacological and pathological alterations in patterns of effective connectivity in the thalamocortical system, the measure hasn't yet been adequately standardized in all its technical aspects. The scholarship student of this project, to be undertaken in the recently approved ICT/UNIFESP Master's program in Biomedical Engineering, will have the task to evaluate the relationships between PCI and the components of its methodology, which includes the spatial-temporal resolution and frequency content of the TMS/hd-EEG signal, as well as the complexity metric used in the calculation of the index. Different versions of the index will be applied over real and simulated TMS/hd-EEG and a standardized version of the index will be proposed and tested in different conditions of altered thalamocortical effective connectivity caused by brain lesions. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

COMOLATTI, RENZO; PIGORINI, ANDREA; CASAROTTO, SILVIA; FECCHIO, MATTEO; FARIA, GUILHERME; SARASSO, SIMONE; ROSANOVA, MARIO; GOSSERIES, OLIVIA; BOLY, MELANIE; BODART, OLIVIER; et al. A fast and general method to empirically estimate the complexity of brain responses to transcranial and intracranial stimulations. BRAIN STIMULATION, v. 12, n. 5, p. 1280-1289, SEP-OCT 2019. (16/08263-9, 17/03678-9)

ARENA, A.; COMOLATTI, R.; THON, S.; CASALI, A. G.; STORM, J. F.. General Anesthesia Disrupts Complex Cortical Dynamics in Response to Intracranial Electrical Stimulation in Rats. ENEURO, v. 8, n. 4, JUL-AUG 2021. (16/08263-9, 17/03678-9)