Identification/elucidation and validation of new targets/pathways involved in osteoarthritis

• Grant number: 17/06736-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: June 01, 2017
• End date: March 20, 2022
• Field of knowledge: Biological Sciences - Immunology - Immunogenetics
• Agreement: GlaxoSmithKline
• Principal Investigator: Olga Celia Martinez Ibanez
• Grantee: Jean Gabriel de Souza
• Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated research grant: 15/50040-4 - Rational approach for searching molecular targets involved in inflammatory events and cell survival, AP.PCPE
• Associated scholarship(s): 19/20713-8 - The role of extracellular ASC in rheumatoid arthritis inflammation, BE.EP.PD

Abstract

The objective of the Centre of Excellence in New Target Discovery (CENTD) is to identify molecular targets involved in inflammatory events and cell survival, focusing in joint diseases (rheumatoid arthritis and osteoarthritis) and cancer, using protein fractions or peptides derived from animal toxins of different origins that are studied in a multidisciplinary way, by the several research groups of the Institute that participate in CENTD. The Immunogenetics Laboratory at Instituto Butantan participates in CENTD and is focused on the study of the genetic control of complex immune characters such as antibody levels and acute inflammatory response intensity. The experimental model is based in pairs of "High" and "low" responder mouse lines that were produced by successive generations of bi-directional selection for these phenotypes. Due to the selection process, profound modifications were also introduced in natural resistance of these lines to infections, in susceptibility to experimental arthritis and to the induction of tumors by chemical carcinogens. In the context of CENTD, the High and Low responder mice will be used as a model system for preclinical tests of the action of in vitro selected compounds in inflammatory joint diseases and cancer. Modern tools will be integrated for the follow-up of the treatment effect over the relevant phenotypes in the resistant and susceptible mice. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BORREGO, ANDREA; COLOMBO, FRANCESCA; DE SOUZA, JEAN GABRIEL; JENSEN, JOSE RICARDO; DASSANO, ALICE; PIAZZA, ROCCO; RODRIGUES DOS SANTOS, BARBARA ANAIS; RIBEIRO, ORLANDO GARCIA; DE FRANCO, MARCELO; KOURY CABRERA, WAFA HANNA; et al. Pycard and BC017158 Candidate Genes of Irm1 Locus Modulate Inflammasome Activation for IL-1 beta Production. FRONTIERS IN IMMUNOLOGY, v. 13, p. 16-pg., 2022-06-21. (17/06736-0, 20/13139-0)

DE SOUZA, JEAN GABRIEL; STAROBINAS, NANCY; IBANEZ, OLGA CELIA MARTINEZ. Unknown/enigmatic functions of extracellular ASC. IMMUNOLOGY, v. 163, n. 4, p. 377-388, AUG 2021. (19/20713-8, 15/50040-4, 17/06736-0)