Comprehensive and Integrative Methylome Analysis Across Endocrine Tumors Harboring the CpG Island Methylator Phenotype (CIMP)

• Grant number: 17/10357-4
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: October 01, 2017
• End date: September 30, 2018
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Houtan Noushmehr
• Grantee: Maritza Queiroz Salas Mosella
• Supervisor: Ana Valeria Castro
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Institution abroad: Henry Ford Health System, United States
• Associated to the scholarship: 16/11039-3 - Charting Epigenomic Signatures in CpG Island Methylator Phenotype (CIMP) Tumors, BP.DR

Abstract

Cancer cells are marked by deregulation of gene expression and genomic instability attributed to genetic mutations and epigenetic alterations that determine active and repressed chromatin. Among the epigenetic modifications, DNA methylation deregulation is a hallmark in cancer. Non-tumoral cells present genome-wide methylation, and hypomethylation in CpG islands (CGIs). In contrast, some cancer types present global genome hypomethylation and widespread CGI hypermethylation, which define the CpG Island Methylator Phenotype (CIMP). CIMP was described in a plethora of cancer types, including some endocrine tumors. The phenotype has shown to participate in the tumorigenic process and showed prognostic and predictive values. Some CIMP cancers have been shown to share common target loci and downstream pathways, however, these commonalities have not been explored across CIMP endocrine tumors. Genomic and epigenetic alterations have been extensively described among the endocrine tumors, but up to now an articulated wide-endocrine analysis still remains, especially encompassing endocrine CIMP cancers and regulatory elements (besides CGIs). Therefore, the aim of this study is to search for epigenomic signatures associated to CIMP endocrine tumors and integrate our findings with other molecular and clinical available data.Key-words: endocrine tumors, hypermethylation, CIMP cancer.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MOSELLA, MARITZA S.; SABEDOT, THAIS S.; SILVA, TIAGO C.; MALTA, TATHIANE M.; DEZEM, FELIPE SEGATO; ASMARO, KARAM P.; WELLS, MICHAEL; MUKHERJEE, ABIR; POISSON, LAILA M.; SNYDER, JAMES; et al. DNA methylation-based signatures classify sporadic pituitary tumors according to clinicopathological features. NEURO-ONCOLOGY, v. 23, n. 8, p. 1292-1303, AUG 2021. (16/11039-3, 14/03989-6, 17/10357-4)