Association between depressive symptoms/depression and hematologic alterations in individuals submitted to a routine medical evaluation

• Grant number: 17/11605-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2017
• End date: August 31, 2018
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Marcelo Katz
• Grantee: Beatriz Piovesana Devito
• Host Institution: Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE). Sociedade Beneficente Israelita Brasileira Albert Einstein (SBIBAE). São Paulo , SP, Brazil

Abstract

Cardiovascular diseases (CVD) are the leading cause of death worldwide and their traditional risk factors were identified in previous studies. Recently, it has been proposed that depressive symptoms and depression could be associated with atherosclerosis and CVD, mediated by inflammatory mechanisms. In addition, some alternative hematologic markers, such as the Red Cell Distribution Width (RDW) and platelet volume, might indicate subclinical inflammatory activity, possibly associated with cardiovascular risk. Therefore, the aim of this study is to analyze the relation between depressive symptoms and the hematologic markers RDW and platelet volume, in individuals submitted to a routine medical evaluation at Hospital Israelita Albert Einstein (AU)