Estradiol influence on leukocyte mobilization and pulmonary inflammation after brain death

• Grant number: 17/11798-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2017
• End date: August 31, 2018
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Ana Cristina Breithaupt Faloppa
• Grantee: Marina Vidal dos Santos
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

The organ transplantation is the treatment of choice for many patients with end-stage disease, where brain death (BD) patients are the main source of transplantation. Clinical and experimental evidence highlight the impact of BD on organ viability to transplant. BD triggers immune system activation, with expression of endothelial adhesion molecules, release of cytokines, chemokines and with the inflammatory cell infiltration to the different organs. Clinical studies point out donor sex as a relevant factor in transplant prognostics. There are evidences of female sex hormones (FSH) in the inflammatory process, since it alters adhesion molecules expression in circulating leucocytes and endothelial cells, also exercising effects on its activation. Previous results using BD experimental model highlight greater inflammatory lung status in female rats in comparison to male rats, likewise showing FSH acute reduction. In ischemia, hemorrhage shock and sepsis model FSH treatment, especially estradiol, has shown protective effects in lung inflammation. Thus, in this project we intent to investigate the continuous estradiol treatment effects in female rats submitted to BD, as a way of controlling lung inflammation. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERNANDA YAMAMOTO RICARDO-DA-SILVA; ROBERTO ARMSTRONG-JR; MARINA VIDAL-DOS-SANTOS; CRISTIANO DE JESUS CORREIA; RAPHAEL DOS SANTOS COUTINHO E SILVA; LUCAS FERREIRA DA ANUNCIAÇÃO; LUIZ FELIPE PINHO MOREIRA; HENRI GERRIT DERK LEUVENINK; ANA CRISTINA BREITHAUPT-FALOPPA. Long–term lung inflammation is reduced by estradiol treatment in brain dead female rats. Clinics, v. 76, 2021-08-16. (16/03692-9, 17/11798-4, 18/07289-0)

RICARDO-DA-SILVA, FERNANDA YAMAMOTO; ARMSTRONG JR, ROBERTO; VIDAL-DOS-SANTOS, MARINA; CORREIA, CRISTIANO DE JESUS; COUTINHO E SILVA, RAPHAEL DOS SANTOS; DA ANUNCIACAO, LUCAS FERREIRA; PINHO MOREIRA, LUIZ FELIPE; DERK LEUVENINK, HENDRIK GERRIT; BREITHAUPT-FALOPPA, ANA CRISTINA. 17 beta-Estradiol Treatment Protects Lungs Against Brain Death Effects in Female Rat Donor. TRANSPLANTATION, v. 105, n. 4, p. 775-784, APR 2021. (17/11798-4, 18/07289-0, 16/03692-9)

RICARDO-DA-SILVA, FERNANDA YAMAMOTO; ARMSTRONG-JR, ROBERTO; VIDAL-DOS-SANTOS, MARINA; CORREIA, CRISTIANO DE JESUS; SILVA, RAPHAEL DOS SANTOS COUTINHO E; ANUNCIACAO, LUCAS FERREIRA DA; MOREIRA, LUIZ FELIPE PINHO; LEUVENINK, HENRI GERRIT DERK; BREITHAUPT-FALOPPA, ANA CRISTINA. Long-term lung inflammation is reduced by estradiol treatment in brain dead female rats. Clinics, v. 76, 2021. (16/03692-9, 17/11798-4, 18/07289-0)