Synthesis of Complex Antibiotics Inspired by Natural Products

• Grant number: 17/18029-6
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: March 01, 2018
• End date: February 28, 2019
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Júlio Cezar Pastre
• Grantee: Luiz Fernando Toneto Novaes
• Supervisor: Thomas Maimone
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Institution abroad: University of California, Berkeley (UC Berkeley), United States
• Associated to the scholarship: 15/08199-6 - Application of Dioxiranes in continuous flow, synthesis of Actinoranone and decalin fragment of Azadirachtin, BP.DR

Abstract

The rise of pathogenic bacteria resistant to known antibiotics is a growing concern with potentially catastrophic consequences as recently noted by The Center for Disease Control. Antibiotic-resistant hospital acquired infections claim over 23,000 lives and cause greater than 2 million illnesses in the United States alone each year. The direct health care costs of such infections have been estimated to be as high as $40 billion USD annually. Microbial evolution, antibiotic misuse, and a significant abandonment of antibiotic drug discovery programs all greatly threaten to return our world to the pre-antibiotic era. Complex natural products and their derivatives have remained at the forefront of antimicrobial drug discovery, yet the development of practical, fully synthetic routes, which offer near limitless structural diversity to combat resistance, still remains challenging. Using advances in synthetic chemistry we will pave the way forward to new, structurally unprecedented antimicrobial agents for the treatment of human infections.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CONDAKES, MATTHEW L.; NOVAES, LUIZ F. T.; MAIMONE, THOMAS J.. Contemporary Synthetic Strategies toward seco-Prezizaane Sesquiterpenes from Illicium Species. Journal of Organic Chemistry, v. 83, n. 24, p. 14843-14852, DEC 21 2018. (17/18029-6)

HUNG, KEVIN; CONDAKES, MATTHEW L.; NOVAES, LUIZ F. T.; HARWOOD, STEPHEN J.; MORIKAWA, TAKAHIRO; YANG, ZHI; MAIMONE, THOMAS J.. Development of a Terpene Feedstock-Based Oxidative Synthetic Approach to the Illicium Sesquiterpenes. Journal of the American Chemical Society, v. 141, n. 7, p. 3083-3099, FEB 20 2019. (17/18029-6)