Effects of iodine treatment over Nrf2 and HO-1 expression in an in vitro model of pre-eclampsia

• Grant number: 17/09140-0
• Support Opportunities: Scholarships in Brazil - Master
• Start date: October 01, 2017
• End date: March 31, 2019
• Field of knowledge: Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
• Principal Investigator: Valeria Cristina Sandrim
• Grantee: Victoria Elizabeth Galvão
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Preeclampsia is a pregnancy complication characterized by high blood pressure detected after the 20th gestational week and other signs of organ damage such as proteinuria, low platelets counting and higher plasmatic concentrations of liver enzymes. It's a condition in which the endothelial nitric oxide synthesis is impaired and therefore vasodilation is not adequate, and oxidative stress is greater due to the pregnant metabolic state, leading to antioxidant genes activation such as Nrf2, a transcription factor that can induce antioxidant enzymes like heme-oxygenase 1 (HO-1). Asian populations such as Japanese and Korean ones are known to be longevous and healthy people regarding their cardiovascular rates, and those people have in common a high iodine daily intake mostly from seaweeds. This rates are not usually sustained when asian subjects immigrate to western countries and adapt to their life style, which includes a poor iodine intake. These studies suggest that diet habits play an important role in these peoples health parameters. Clinical evidences show that preeclamptic women have lower iodine urinary excretion with no significant differences in plasmatic thyroid hormones levels, which might be due to other extrathyroid effects of iodine. Thus, this study aims to assess a possible endothelial protective role of iodine when those cells are challenged with preeclamptic women's plasma, by the activation of antioxidant transcription factor Nrf2 and HO-1. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GALVAO, VICTORIA ELIZABETH; CAVALLI, RICARDO CARVALHO; SANDRIM, VALERIA CRISTINA. reeclampsia and Gestational Hypertension: Biochemical and Antioxidant Features in Vitro Might Help Understand Different Outcome. Revista Brasileira de Ginecologia e Obstetrícia, v. 43, n. 12, p. 894-903, DEC 2021. (15/20461-8, 17/09140-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

GALVÃO, Victoria Elizabeth. Effects of potassium iodide treatment over HUVEC's incubated with plasma from pregnant women diagnosed with hypertensive disorders of pregnancy. 2019. Master's Dissertation - Universidade Estadual Paulista (Unesp). Instituto de Biociências. Botucatu Botucatu.