| Grant number: | 17/18757-1 |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| Start date: | November 01, 2017 |
| End date: | October 31, 2018 |
| Field of knowledge: | Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery |
| Principal Investigator: | José Paes de Oliveira Filho |
| Grantee: | Julia Franco Ferreira |
| Host Institution: | Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil |
Abstract The Quarter Horse breed has stood out due to its phenotypic qualities, representing a significant portion of the horse population in Brazil. However, some undesirable traits, including genetic diseases, can be perpetuated when asymptomatic carriers are used as reproducers.Thus, the identification of the presence of genetic mutations in a population is necessary. Among the hereditary alterations described in horses, some lead to hemostasis disorders, culminating in clinical signs commonly described in animal athletes, such as epistaxis. Glanzmann's thrombasthenia (GT) is an autosomal recessive disease caused by mutations in the ±IIb²3 integrin protein coding gene, which results in changes in platelet aggregation and absence of clot retraction, manifesting clinically as bleeding and epistaxis. The objective of this research will be to determine the prevalence of 10-base-pair deletion in the ITGA2B gene that causes Glanzmann Thrombastenia in a cohort of the Quarter Horses. (AU) | |
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