COMPLEXATION OF RIFAXIMIN TO CYCLODEXTRIN AND THERMAL AND SPECTROSCOPIC STUDY OF FORMED COMPLEX

• Grant number: 17/18907-3
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• Start date: March 01, 2018
• End date: April 30, 2018
• Field of knowledge: Health Sciences - Pharmacy - Medicines Analysis and Control
• Principal Investigator: Hérida Regina Nunes Salgado
• Grantee: Ana Carolina Kogawa
• Supervisor: Leena Peltonen
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Institution abroad: University of Helsinki, Finland
• Associated to the scholarship: 14/22019-8 - CHEMICAL-PHARMACEUTICAL ANALYSIS OF RIFAXIMIN IN RAW MATERIAL AND TABLETS, SHORT TERM STABILITY, DISSOLUTION AND POLYMORPHISM STUDIES., BP.PD

Abstract

Rifaximin is an oral antimicrobial, intestine - selective, with low level selection for mutations of resistant bacteria and no systemic with adverse effects compared to placebo. It is used for the treatment of hepatic encephalopathy, travelers' diarrhea, syndrome of irritable bowel, Clostridium difficile, ulcerative colitis and acute diarrhea. Rifaximin has low solubility in water, therefore it requires administration at relatively high doses for the success of the therapeutic effect. The complexation of drugs using cyclodextrins is welcome in this aspect by improving solubility and, consequently, increasing the rate of dissolution of poorly soluble drugs. This fact justifies new research in this area. Thus, this project aims to (i) perform the complexation of rifaximin to different cyclodextrins; (ii) study the inclusion complex formed by thermal and spectroscopic techniques; (iii) evaluate the stability of the formed complex and also (iv) to test the increase of solubility of rifaximin via nanonization by wet milling or precipitation techniques or making amorphous material.