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MLH1 and MLH2 gene expression in buccal squamous cell carcinoma

Grant number: 17/21227-4
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Start date: December 01, 2017
End date: November 30, 2018
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Mônica Ghislaine Oliveira Alves
Grantee:Natália da Silva Miguel
Host Institution: Universidade Braz Cubas (UBC). Mogi das Cruzes , SP, Brazil

Abstract

The aim of the present paper is the evaluation of DNA repair in cases of squamous cell carcinoma (SCC), through the evaluation of important genes that play this role. It will be considered two groups for analysis: Group 1, with 30 CCE lesions; Group 2, with 30 fragments of buccal tissues with a clinical aspect of normality obtained by removing at the border of biopsy specimens from benign lesions of patients equivalent, in sex and age, to patients in group 1. Gene expression will be evaluated by means of qPCR for the repair genes MLH1 and MSH2. All the results were correlated with the clinical data of cases of SCC. Data is analyzed using GraphPad Prism 5.03 software. The groups were compared using Student's t-test, with p <0.05 indicating a significant difference. The associations between gene expression levels and clinical data will be explored using the Pearson correlation coefficient. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
OLIVEIRA ALVES, MONICA GHISLAINE; MIGUEL, NATALIA DA SILVA; PANISELLO FERREIRA, CAMILA CRISTINA; ALVARENGA, ELIS RIBEIRO; TONON, BRUNA MANZANARES; DE BARROS, PATRICIA PIMENTEL; LIMA CARTA, CELINA FAIG; NOGUEIRA PASCHOAL, MARIA BEATRIZ; DE SALES CHAGAS, JOSE FRANCISCO; BANDEIRA, CELSO MULLER; et al. Expression of DNA repair in oral squamous cell carcinoma using reverse transcription-quantitative polymerase chain reaction. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, v. 130, n. 3, p. 8-pg., . (16/08633-0, 17/23179-7, 17/21227-4)