| Grant number: | 17/21227-4 |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| Start date: | December 01, 2017 |
| End date: | November 30, 2018 |
| Field of knowledge: | Health Sciences - Dentistry |
| Principal Investigator: | Mônica Ghislaine Oliveira Alves |
| Grantee: | Natália da Silva Miguel |
| Host Institution: | Universidade Braz Cubas (UBC). Mogi das Cruzes , SP, Brazil |
Abstract The aim of the present paper is the evaluation of DNA repair in cases of squamous cell carcinoma (SCC), through the evaluation of important genes that play this role. It will be considered two groups for analysis: Group 1, with 30 CCE lesions; Group 2, with 30 fragments of buccal tissues with a clinical aspect of normality obtained by removing at the border of biopsy specimens from benign lesions of patients equivalent, in sex and age, to patients in group 1. Gene expression will be evaluated by means of qPCR for the repair genes MLH1 and MSH2. All the results were correlated with the clinical data of cases of SCC. Data is analyzed using GraphPad Prism 5.03 software. The groups were compared using Student's t-test, with p <0.05 indicating a significant difference. The associations between gene expression levels and clinical data will be explored using the Pearson correlation coefficient. (AU) | |
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