Influence of glycemic control in arterial stiffness and functional performance in elderly with type 2 Diabetes

• Grant number: 17/19853-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: January 01, 2018
• End date: December 31, 2019
• Field of knowledge: Health Sciences - Physiotherapy and Occupational Therapy
• Principal Investigator: Renata Gonçalves Mendes
• Grantee: Guilherme Romano Migliato
• Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

Introduction: Type 2 diabetes mellitus (DM2) is a prevalent disease in the elderly and is associated with vascular impairment and physical-functional limitations, which can be attenuated or enhanced by glycemic control. Objective: To investigate whether glycemic control influences arterial stiffness and functional performance in elderly patients with T2DM. Method: Will be included volunteers with diagnosis of DM2, of both sexes, with more than 60 years. They will be divided into two groups, according to glycated hemoglobin levels: HbA1C <7% (satisfactory glycemic control) and HbA1C and 7% (unsatisfactory glycemic control). Both groups will be submitted to the following evaluations: 1) Arterial rigidity, by analysis of carotid-femoral pulse wave velocity (OPV-cf); and by amplification index (AIx) 2) Functional performance, evaluated by sit-and-lift test of 30 seconds, and 10-meter walking speed test. The intergroup comparison will be performed by unpaired and Mann-Whitney t tests. Associations will be established by the Pearson or Spearman correlation coefficient. In all analyzes, the result will be significant when p <5%. Expected results: Based on the obtained results, we expect to confirm the following hypotheses: a) elderly patients with T2DM and unsatisfactory glycemic control present higher arterial stiffness and worse functional performance when compared to those with good glycemic control; b) there is a positive association between arterial stiffness and functional performance in elderly patients with T2DM. Contributions: It is intended to elucidate the influence of glycemic control as a contributing factor for the development of vascular alterations and functional deficits in elderly with T2DM. In this way, it will be possible to propose specific prevention. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

HEUBEL, ALESSANDRO DOMINGUES; KABBACH, ERIKA ZAVAGLIA; MIGLIATO, GUILHERME ROMANO; RUSSO, MARIA ISABELLA SANTOS; BRANDAO, GUSTAVO MUCOUCAH SAMPAIO; ROSCANI, MELIZA GOI; BORGHI-SILVA, AUDREY; MENDES, RENATA GONCALVES. Role of arterial stiffness and endothelial dysfunction on lower limb performance in older adults with type 2 diabetes: A cross-sectional study. JOURNAL OF DIABETES AND ITS COMPLICATIONS, v. 36, n. 8, p. 6-pg., 2022-08-04. (17/19853-4)