Pyruvate metabolism function identification in Trypanosoma cruzi

• Grant number: 17/25084-3
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: March 01, 2018
• End date: February 29, 2020
• Field of knowledge: Biological Sciences - Parasitology - Protozoology of Parasites
• Principal Investigator: Roberto Docampo
• Grantee: Raquel Silva de Negreiros
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 13/50624-0 - Calcium signaling in trypanosomatids, AP.SPEC

Abstract

We will investigate whether the mitochondrial pyruvate carrier (MPC) is essential for the regulation of ATP synthesis by Ca2+. The pyruvate carrier comprises two small hydrophobic proteins MPC1 and MPC2 that have been recently identified. We will investigate whether the regulation of pyruvate availability through the action of the MPC is responsible for balancing oxidative phosphorylation and glycolysis in the different life cycle stages of T. cruzi.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NEGREIROS, RAQUEL S.; LANDER, NOELIA; CHIURILLO, MIGUEL A.; VERCESI, ANIBAL E.; DOCAMPO, ROBERTO. Mitochondrial Pyruvate Carrier Subunits Are Essential for Pyruvate-Driven Respiration, Infectivity, and Intracellular Replication of Trypanosoma cruzi. MBIO, v. 12, n. 2, MAR-APR 2021. (17/25084-3, 13/50624-0)