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Effect of pre-operative fitness in pulmonary complications, hospitalization duration, functional capacity, quality of life and mortality on patients undergoing major oncological surgery: controlled and randomized trial

Grant number: 17/24276-6
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2018
Effective date (End): September 30, 2020
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Adriana Claudia Lunardi
Grantee:Isabel Fialho Fontenele Garcia
Home Institution: Pró-Reitoria de Pós-Graduação, Pesquisa e Extensão. Universidade Cidade de São Paulo (UNICID). São Paulo , SP, Brazil

Abstract

If surgical resection is indicateto treat Cancer, postoperative pulmonary complications (CPPs) may occur. Preoperative fitness is beneficial on thoracic and abdominal surgeries, but it has still been poorly tested in other major surgeries. Objectives: To evaluate the effects of preoperative fitness on the incidence of CPPs, functional capacity, length of hospitalization, quality of life and postoperative mortality on patients undergoing major oncologic surgery. Methods: A randomized controlled trial that will involve 54 patients with Cancer who are awaiting for surgical treatment at the Instituto de Assistência Médica ao Servidor Público Estadual. The intervention group will perform physical conditioning with aerobic exercise. Treadmill and resisted lower limb exercises will be performed 3 times per week, on non consecutive days during 4 weeks. The control group will receive placebo treatment with guidance to perform 10 breaths, twice per day, on non-consecutive days during 4 weeks. The groups will be compared by means of the t-test or Mann-Whitney on functional capacity test (Incremental Shuttle Walk Test) and quality of life (European Organization for Research and Quality of Life Questionnaire Core-30) before and after the intervention. In addition, the incidence of CPPs and postoperative mortality will be compared by chi-square test. The length of hospitalization will be compared by Kaplan-Meier survival analysis. Recruitment, adherence, treatment satisfaction and adverse events rates will also be checked. (AU)