Synthesis of naphthyridines with potential tubulin inhibitory activity

• Grant number: 18/07555-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2018
• End date: January 20, 2020
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Fernando Antonio Santos Coelho
• Grantee: Beatriz Moura Donolato
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

This undergraduated research project intends to synthesize new naphthyridines with potential tubulin inhibitory activity. These compounds can be used as anti-tumoral agents. Previous studies in silico have demonstrated the potentiality of these heterocycles. The required naphthyridines will be prepared according a methodology previously developed in our laboratory, using as building blocks for the heterocyclic syntheses, the Morita-Baylis-Hillman adducts synthesized from 2-halopyridinecarbaldehydes and 2-haloquinolinecarbaldehydes.