Effects of treatment with ACT1 treatment on cell proliferation of B16 melanoma and canine melanoma cells.

• Grant number: 18/11202-7
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: September 01, 2018
• End date: August 31, 2019
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Pathology
• Principal Investigator: Maria Lucia Zaidan Dagli
• Grantee: Ayami Sato
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Oral melanoma is the most common type of tumor in the oral cavity of dogs, and although surgery is the most recommended treatment, relapse is common, as the tumor can often not be completely excised. Adjuvant therapies such as chemotherapy and radiotherapy also do not guarantee prolonged survival because of the aggressiveness of this tumor. A study conducted at the Laboratory of Experimental and Comparative Oncology at FMVZ / USP found that canine melanomas express connexin 43 (TEIXEIRA et al., 2014). In partnership with the researcher Elizabeth S. Yeh, we will test the ACT1 peptide that has antitumor activity by mimicking the cytoplasmic domain of cx 43. Therefore, the ACT 1 peptide can be tested as a treatment in canine melanomas, and if it shows antitumor results, it will be a an advance of great importance for veterinary medicine, since this tumor does not have effective treatment.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SATO, AYAMI; DA FONSECA, IVONE IZABEL MACKOWIAK; NAGAMINE, MARCIA KAZUMI; DE TOLEDO, GABRIELA FERNANDES; OLIO, RENNAN; HERNANDEZ-BLAZQUEZ, FRANCISCO JAVIER; YANO, TOMOHIRO; YEH, ELIZABETH SHINMAY; DAGLI, MARIA LUCIA ZAIDAN. Effects of Alpha-Connexin Carboxyl-Terminal Peptide (aCT1) and Bowman-Birk Protease Inhibitor (BBI) on Canine Oral Mucosal Melanoma (OMM) Cells. FRONTIERS IN VETERINARY SCIENCE, v. 8, JUN 10 2021. (16/20479-7, 18/11202-7, 17/12855-1, 18/16515-3)