Understanding the cross-talk between SUMOylation and oxidative stress in Plasmodium falciparum

• Grant number: 18/10150-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2018
• End date: March 31, 2021
• Field of knowledge: Biological Sciences - Parasitology - Protozoology of Parasites
• Principal Investigator: Carsten Wrenger
• Grantee: Daffiny Sumam de Oliveira
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 15/26722-8 - Drug discovery against human infectious diseases, AP.TEM
• Associated scholarship(s): 19/26771-0 - Structural evaluation of the SUMOlation activation in the human malaria parasite Plasmodium falciparum, BE.EP.IC

Abstract

Malaria is a devastating disease in the tropics which includes the sub-Sahara region in Africa as well as the Amazon region of Brazil. Until now a potent vaccine is not available and therefore the treatment of malaria is solely dependent on chemotherapy. Currently the treatment is based on Arteminsin combined therapies (ACT), however first resistance are already occurring in Thailand. This situation accelerates the necessity of novel drugs with new pharmaceutical targets for efficient treatment. In this context it became apparent that SUMOlation of proteins might have a protective role in oxidative stress mediation. In this project we would like to focus on the SUMOlation process during the presence of oxidative stress mediated by parasite proliferation in glucose-6-phosphate dehydrogenase (G6PD)-deficient erythrocytes.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SUMAM DE OLIVEIRA, DAFFINY; KRONENBERGER, THALES; PALMISANO, GIUSEPPE; WRENGER, CARSTEN; DE SOUZA, EDMARCIA ELISA. Targeting SUMOylation in Plasmodium as a Potential Target for Malaria Therapy. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 11, JUN 10 2021. (18/10150-3, 20/04923-0, 19/26771-0, 20/12277-0, 17/03966-4, 18/18257-1, 18/15549-1, 15/26722-8)