| Grant number: | 19/02490-1 |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |
| Start date: | May 21, 2019 |
| End date: | May 20, 2020 |
| Field of knowledge: | Biological Sciences - Physiology - Physiology of Organs and Systems |
| Principal Investigator: | Terezila Machado Coimbra |
| Grantee: | Lucas Ferreira de Almeida |
| Supervisor: | Kirsten Madsen |
| Host Institution: | Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil |
| Institution abroad: | University of Southern Denmark (SDU), Denmark |
| Associated to the scholarship: | 17/07118-8 - Influence of vitamin D on renal development in rats, BP.DR |
Abstract Adverse events during fetal development are associated with increased risk of hypertension and cardiovascular and metabolic diseases later in life, a correlation know as fetal programing. The kidneys are particularly prone to fetal programming alterations specially when there is a disruption on the renin-angiotensin cascade during development. One of the specific targets of these alterations is the kidney vasculature. An elegant study by professor Madsen's group, using unbiased quantitative stereologic methods demonstrated a reduction in expansion for postglomerular recta bundles in rats during lactation in response to pharmacological AT1 receptor antagonism in the postnatal period. The long-term effects of this receptor blockade are still yet to be investigated. Thus, we propose an elegant collaborative study between the two research groups to explore the long term effects of the pharmacological blockage of AT1. We hypothesized that postnatal development of the kidney depends on AngII-stimulated angiogenesis and that medullary injury after RAS inhibition is caused by impaired development of the microvasculature that persists in adulthood. The hypothesis will be addressed in vivo by application of unbiased quantitative stereologic methods. Postglomerular microvascular length, volume, and surface area will be determined in rat kidneys at P 90 after treatment with AngII type 1 (AT1) inhibitor during the 10-15 days of postnatal life. Mechanisms will be addressed by analysis of novel signaling pathways involved in angiogenesis in the renal medulla during kidney development. The obtained results will make possible the comparison with the Vit.D deficiency results previously obtained in our laboratory. | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
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