Characterization of exosomes towards new therapeutic approaches for gestational diabetic myopathy

• Grant number: 19/02405-4
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• Start date: October 30, 2019
• End date: March 21, 2020
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Marilza Vieira Cunha Rudge
• Grantee: Juliana Ferreira Floriano
• Supervisor: Costanza Emanueli
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Institution abroad: Imperial College London, England
• Associated to the scholarship: 17/21783-4 - Gestational triad cohort: hyperglycemia, urinary incontinence and clinical, molecular and omic profile of hyperglycemic myopathy in predicting incontinence and muscle dysfunction and translational research with biodevice for muscle regeneration in rats, BP.PD

Abstract

Gestational diabetes promotes deleterious effects on the pelvic floor and rectus abdominis muscles, leading to urinary incontinence in these women up to two years postpartum due to gestational diabetic myopathy, a condition characterized by several muscular alterations and atrophy. The research group Diamater has intensified its efforts in the understanding and treatment of this pathology. Currently the treatment for diabetic gestational myopathy and urinary incontinence is ineffective, raising public health costs and decreasing the quality of life of women. Therefore, it is necessary to develop new research in this area in order to clarify the pathophysiology, identify biomarkers that act in the early and effective diagnosis and also develop research aimed at the therapy of gestational diabetic myopathy. Recently, the study of exosomes has been shown to be effective not only as a biomarker for pathologies, but also for studies of the pathophysiology and and effective, safe and cell-free therapy. For this reason, this research project aims improving the study of pathophysiology and identification of new biomarkers for gestational diabetic myopathy, improving and creating new perspectives for the translational use of therapy proposed in thematic process number: 2016 / 01743-5. By developing new pilot data that investigates the potential of circulating exosomes to improve the prediction, diagnosis, and treatment of gestational diabetes mellitus (GDM)-induced pelvic floor myopathy and the exosomes derived from mesenchymal stem cells (MSCs) may represent new therapeutic approach.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FLORIANO, JULIANA FERREIRA; WILLIS, GARETH; CATAPANO, FRANCESCO; DE LIMA, PATRICIA RODRIGUES; DUARTE SOUZA REIS, FABIANA VIEIRA; PASCON BARBOSA, ANGELICA MERCIA; CUNHA RUDGE, MARILZA VIEIRA; EMANUELI, COSTANZA. Exosomes Could Offer New Options to Combat the Long-Term Complications Inflicted by Gestational Diabetes Mellitus. CELLS, v. 9, n. 3, MAR 2020. (19/02405-4)

OZAKI TAN, SHO JOSEPH; FLORIANO, JULIANA FERRERIA; NICASTRO, LAURA; EMANUELI, COSTANZA; CATAPANO, FRANCESCO. Novel Applications of Mesenchymal Stem Cell-Derived Exosomes for Myocardial Infarction Therapeutics. BIOMOLECULES, v. 10, n. 5, MAY 2020. (19/02405-4)