Study of hepatocellular regeneration, hemodynamic and portal modulation in liver transplantation

• Grant number: 17/21478-7
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: April 01, 2019
• End date: March 31, 2021
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Lucas Souto Nacif
• Grantee: Leonardo Yuri Kasputis Zanini
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Small-for-Size (SFS) syndrome develops after liver transplantation or an enlarged liver resection. It is the fundamental obstacle for the clinical use of partial liver grafts and for the accomplishment of extensive liver resections in cases of intrahepatic and hilar tumors. The rapid and excessive proliferation of hepatocytes has severe changes in tissue microstructure, which makes this liver mass regenerated without proper functioning, and this phenomenon is decisive in the pathogenesis of SFS syndrome. Studies may offer the opportunity to define not only where the limits are to perform transplantation with partial graft safely, as well as better hemodynamic evaluation. The objective of this work will be to evaluate and establish a clinical study of hemodynamics and portal modulation in liver transplantation and porto-cava anastomosis.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NACIF, LUCAS SOUTO; ZANINI, LEONARDO YURI; WAISBERG, DANIEL REIS; COSTA DOS SANTOS, JOAO PAULO; PEREIRA, JULIANA MARQUEZI; PINHEIRO, RAFAEL SOARES; ROCHA-SANTOS, VINICIUS; MARTINO, RODRIGO BRONZE; ARANTES, RUBENS MACEDO; DUCATTI, LILIANA; et al. Adult -to -Adult Living Donor Liver Transplant: Hemodynamic Evaluation, and Selection. Transplantation Proceedings, v. 52, n. 5, p. 1299-1302, JUN 2020. (17/21478-7)