Evaluation of total vascular S-nitrosylation in CLP septic animals

• Grant number: 19/03334-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: April 01, 2019
• End date: March 31, 2020
• Field of knowledge: Biological Sciences - Pharmacology - General Pharmacology
• Principal Investigator: Lucas Cezar Pinheiro
• Grantee: Isvander Gustavo de Souza Persona
• Host Institution: Escola de Enfermagem de Ribeirão Preto (EERP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 17/07570-8 - Proteic nitrosylation: a critical mechanism and pharmacological target in severe sepsis, AP.JP

Abstract

Sepsis is a serious condition with great mortality. The worsening of sepsis may result in septic shock, in which a significant drop in blood pressure, usually refractory to vasoconstricting agents, occurs. Such events may be associated with increased nitric oxide formation and consequent increase in S-nitrosylation of proteins. The aim of the project is to evaluate whether there is an increase in S-nitrosylated proteins in the vasculature after sepsis.