Effect of cervical skin cooling in the reduction of 68GaPSMA uptake in salivary glands of patients with prostate cancer

• Grant number: 19/00808-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2019
• End date: July 31, 2020
• Field of knowledge: Health Sciences - Medicine - Medical Radiology
• Principal Investigator: Marcelo Tatit Sapienza
• Grantee: Matheus Zanelatto Junqueira
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Prostate cancer is the most common malignant neoplasm in men, excluding non-melanoma skin tumors, accounting for approximately 25% of the new cancers diagnosed in the Brazilian male population. Radioligand therapies have shown promise in the treatment of specific neoplasms. Lutetium-177 labeled PSMA (177Lu-PSMA-617) has been used for patients with metastatic carcinoma resistant to chemical castration (mCPMRC). However ionizing radiation can induce lesions in the salivary glands, causing discomfort and complaints such as "dry mouth" and halitosis, which can occur frequently when the dose of radiation exceeds the limits of 40Gy. In the treatment with 177Lu-PSMA, the salivary gland is the organ with the highest radiation absorbed dose (approximately 1.0 Gy / GBq). Specific measures may be employed in an attempt to reduce the dose of radiation absorbed by the salivary glands, in order to reduce the side effects. Cervical cutaneous cooling is one of the measures proposed empirically to reduce the uptake in salivary glands. This project aims to determine the effect of salivary gland cooling on the reduction of 68Ga-PSMA radiopharmaceutical uptake, which has an uptake mechanism similar to 177Lu-PSMA, in order to predict the efficacy of the maneuver in decreasing the radiation dose in the salivary glands in a therapeutic context.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MATHEUS ZANELATTO JUNQUEIRA; NELISA HELENA ROCHA; MARCELO TATIT SAPIENZA. PET/CT com 68Ga-PSMA: efeitos do resfriamento externo na captação pelas glândulas salivares. Radiologia Brasileira, v. 54, n. 3, p. 171-176, 2021-05-24. (19/00808-4)

JUNQUEIRA, MATHEUS ZANELATTO; ROCHA, NELISA HELENA; SAPIENZA, MARCELO TATIT. Ga-68-Prostate-Specific Membrane Antigen PET/CT Uptake in Intraventricular Meningioma in the Choroid Plexus. CLINICAL NUCLEAR MEDICINE, v. 46, n. 1, p. 2-pg., 2021-01-01. (19/00808-4)