Zika Virus Irreversible Inactivation by Dendritic Copolymers as Broad-Spectrum Antiviral Agents

• Grant number: 19/17028-1
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• Start date: October 28, 2019
• End date: October 27, 2020
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Mateus Borba Cardoso
• Grantee: Lívia Mesquita Dias Loiola
• Supervisor: Alexander N. Zelikin
• Host Institution: Centro Nacional de Pesquisa em Energia e Materiais (CNPEM). Ministério da Ciência, Tecnologia e Inovação (Brasil). Campinas , SP, Brazil
• Institution abroad: Aarhus University, Denmark
• Associated to the scholarship: 16/21598-0 - Functionalized silica nanoparticles: a strategy for Zika virus inactivation, BP.PD

Abstract

Besides significant advances in the last centuries, humanity still suffer from a plenty of viral diseases for which we have no vaccines or specific treatments. Development of prevention or treatment measures for emerging viral diseases has been proven difficult and expensive. The solution to this problem may reside in molecules that are broadly active, protective against different viruses, also known as broad-spectrum antiviral agents. Herein we propose the development of dendritic polyanions-based materials, that may act as virustatic polymers ultimate leading to virus irreversible distortion, as a consequence of the multivalent bind to viruses particles. The predicted permanent virus inactivation response of the designed dendritic polymers, specially focused on Brazilian ZIKV, would make them virucidal therapeutic strategies against viral infections in humans.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GROSS, RUDIGER; DIAS LOIOLA, LIVIA MESQUITA; ISSMAIL, LEILA; UHLIG, NADJA; EBERLEIN, VALENTINA; CONZELMANN, CARINA; OLARI, LIA-RALUCA; RAUCH, LENA; LAWRENZ, JAN; WEIL, TATJANA; et al. Macromolecular Viral Entry Inhibitors as Broad-Spectrum First-Line Antivirals with Activity against SARS-CoV-2. ADVANCED SCIENCE, v. N/A, p. 17-pg., 2022-05-11. (15/25406-5, 19/17028-1)