The development of a catalytic system that avoids the oxidation of alcohols to the corresponding carbonyl compounds

• Grant number: 19/27528-1
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: March 01, 2020
• End date: May 31, 2023
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Emílio Carlos de Lucca Júnior
• Grantee: Victor Camargo Stork Santana
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 18/04837-6 - Oxidation of aliphatic C-H bonds catalyzed by transition metals, AP.JP

Abstract

Considering the several challenges for the functionalization of C-H bonds which are very unreactive and have adversities in selectivity with electrophilic reagents, the present research project proposes the use of first period transition metals for metal catalysis as a way of activating methylenic C-H bonds, without the oxidation of the corresponding alcohol to ketone. The first step is the synthesis of ligands associated with metals such as iron and manganese, which will then be evaluated for generality, selectivity and reactivity for oxidation of C(sp3)-H bonds. Finally, optimized catalytic conditions will be applied in the synthesis of products of interest to large areas of Chemistry and Biology. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SANTANA, VICTOR C. S.; FERNANDES, MILENA C., V; CAPPUCCELLI, ISADORA; RICHIERI, ANA CAROLINA G.; DE LUCCA JR, EMILIO C.. Metal-Catalyzed C-H Bond Oxidation in the Total Synthesis of Natural and Unnatural Products. SYNTHESIS-STUTTGART, v. 54, n. 24, p. 23-pg., 2022-10-06. (18/04837-6, 19/27528-1, 21/07167-4)

SANTANA, VICTOR C. S.; ROCHA, EDUARDO C. S.; PAVAN, JULIAN C. S.; HELENO, VLADIMIR C. G.; DE LUCCA JR, EMILIO C.. Selective Oxidations in the Synthesis of Complex Natural ent-Kauranes and ent-Beyeranes. Journal of Organic Chemistry, v. N/A, p. 5-pg., 2022-07-21. (18/04837-6, 21/01918-8, 19/27528-1)