Evaluation of HER-2 expression heterogeneity and antitumor effect of Lapatinibe in canine osteosarcomas

• Grant number: 19/24468-8
• Support Opportunities: Scholarships in Brazil - Master
• Start date: June 01, 2020
• End date: February 28, 2022
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Carlos Eduardo Fonseca Alves
• Grantee: Mayara Simão Franzoni
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

r is one of the causes of higher mortality in dogs, and osteosarcoma is a type of bone neoplasia that has a high incidence in this species. Recent research has shown that HER-2, a tyrosine kinase receptor, is expressed in this type of tumor, and is associated with poor survival and chemotherapy resistance, in addition to stimulating cell differentiation, migration, apoptosis and angiogenesis, thus blocking This pathway may prevent cell differentiation and migration, induce neoplastic cell apoptosis and decrease angiogenesis. Currently the treatment of choice for canine osteosarcoma is amputation of the affected limb associated with chemotherapy, usually with doxorubicin. Due to new findings in relation to HER-2, new therapies are under development. Lapatinib is a drug that inhibits phosphorylation of this receptor and will be tested in osteosarcoma cell cultures collected at the Veterinary Hospital of the Faculty of Veterinary Medicine and Animal Husbandry. UNESP de Botucatu, in order to compare its antineoplastic effect with the effect of Doxorubicin, besides characterizing the expression of HER-2 in these samples, since there are few studies with this information regarding osteosarcoma in dogs. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FRANZONI, Mayara Simão. Evaluation of heterogeneity of HER-2 expression and antitumor effect of lapatinib in canine osteosarcomas. 2022. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Medicina Veterinária e Zootecnia. Botucatu Botucatu.