Study of hippocampal neurotransmission involvement in the central mechanisms of chronic repeated stress-induced behavioral responses

• Grant number: 21/04572-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2021
• End date: December 31, 2022
• Field of knowledge: Biological Sciences - Pharmacology - Neuropsychopharmacology
• Principal Investigator: Cristiane Busnardo Santiago
• Grantee: Luana Omena Giatti
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Associated research grant: 18/04899-1 - Genetic study of hypocampus glutamate neurotransmission in central mechanisms of the adaptation of neuroendocrine, cardiovascular and behavioral responses to repeated chronic stress and stress-induced neuroinflamation, AP.JP

Abstract

Emotional stress causes a physiological and psychological imbalance in the body. Adaptive processes are triggered during repeated exposure to stress that constitutes important changes minimizing stress impact on the body. An important adaptive process is physiological response habituation during repeated exposure to the same aversive stimulus. These physiological responses are accompanied by emotional consequences such as the development of anxiety and depression disorders, which appear to be due to an abnormal stress adaptation. However, despite the importance of stress responses habituation, neurobiological and neurochemical mechanisms involved in this process are still poorly understood. Therefore, the aim of the present project is to evaluate the effect of ventral and dorsal hippocampal neurons inactivation (through the Daun02 inactivation method) previously activated by restraint stress on the behavioral responses associated with chronic restraint stress in c-Fos-lacZ transgenic rats. (AU)