Evaluation of torque teno virus in blood and saliva of cirrhotic patients

• Grant number: 21/00708-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2021
• End date: December 31, 2021
• Field of knowledge: Health Sciences - Dentistry
• Principal Investigator: Karem López Ortega
• Grantee: Ana Clara Falabello de Luca
• Host Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

A cirrhotic liver is deficient in several physiological processes in the body, such as the important damage to the immune system, mainly due to the failure of the reticuloendothelial system. The development of immune dysfunction associated with cirrhosis corresponds to a systemic inflammation, which causes an important immunodeficiency state in these patients. Another physiological process affected in cirrhotic patients is excretion, which results in the accumulation of toxic nitrogenous components, which can potentiate systemic inflammation and contribute to viral latency. Thus, it is necessary to investigate the viral load present in these patients, and its relationship with the clinical picture of cirrhosis, in order to understand the relationship between the incidence of viral infection and the state of immunosuppression in these patients. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE LUCA, ANA CLARA FALABELLO; MARINHO, GABRIELLA BUENO; FRANCO, JULIANA BERTOLDI; TENORIO, JEFFERSON DA ROCHA; ANDRADE, NATALIA SILVA; BATISTA, ALEXANDRE MENDES; MAMANA, ANA CAROLINA; TOZETTO-MENDOZA, TANIA REGINA; SAYANS, MARIO PEREZ; BRAZ-SILVA, PAULO HENRIQUE; et al. Quantification of Torque Teno Virus (TTV) in plasma and saliva of individuals with liver cirrhosis: a cross sectional study. FRONTIERS IN MEDICINE, v. 10, p. 7-pg., 2023-06-22. (21/00708-0, 17/18938-6, 21/07490-0)