Role of NLRP3 inflammasome on the cardiac function in Hypothyroid animals

• Grant number: 21/06151-7
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: August 01, 2021
• End date: May 31, 2024
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Maria Luiza de Morais Barreto de Chaves
• Grantee: Aline Cristina Parletta
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 19/17031-2 - Inflammasome in the cardiac physiopathology, AP.TEM

Abstract

Long-term hypothyroidism is associated with cardiac fibrosis (due to neutrophil infiltration) and ventricular dilation, which can culminate in heart failure. Studies show that HTs deficiency leads to an increase in inflammatory markers, such as C-Reactive Protein (CRP), TNF-alpha, IL-6 and GFR-beta1 and the restoration to a condition of euthyroidism, although it promotes improvement in cardiac function, appears to result in even higher levels of inflammatory and fibrotic markers in both plasma and heart. The main objective of this work is to investigate whether the suppression of NLRP3 inflammama can contribute to the prevention of the pathological condition caused by Hypothyroidism. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PARLETTA, ALINE; VIEIRA JUNIOR, DENIVAL; SENGER, NATHALIA; BARRETO-CHAVES, MARIA LUIZA. Nlrp3 inflammasome in the heart of hypothyroid mice. PHYSIOLOGY, v. 38, p. 2-pg., 2023-05-01. (21/06151-7, 19/17031-2)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

PARLETTA, Aline Cristina. Role of the NLRP3 inflammasome in models associated with cardiac remodeling.. 2024. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.