Design, computational studies, synthesis and pharmacological evaluation of novel pyrrolidine derivatives as ligands of the alpha4beta2 nicotinic acetylcholine receptors (nAChRs).

• Grant number: 21/05026-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2021
• End date: July 31, 2022
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Nailton Monteiro Do Nascimento Júnior
• Grantee: Andressa de Lima Neves
• Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Virtual screening and synthesis of novel pyrrolidine derivatives are proposed aiming pharmacological activity against the alpha 4 beta 2 nicotine acetylcholine receptors (nAChRs). The pharmacological avaluation will be performed in collaboration.