Evaluation of the immunomodulatory effect by prednisone drug carried on lipid nanoparticles in a 3D experimental model of Crohn's Disease

• Grant number: 21/02207-8
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: September 01, 2021
• End date: August 31, 2025
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Antonio Claudio Tedesco
• Grantee: Nayara Rezende
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

In this proposal, we intend to develop Delivery Drug Systems (DDS) targeted to receptors of IL-12/IL-23 pro-inflammatory cytokines by specific monoclonal antibodies, seeking to investigate specific uptake and the effect of the drug prednisone in 2D and 3D cellular matrices of the intestinal epithelium of Crohn's Disease patients. The DDS aims to improve the therapeutic efficacy of medicines, directly reflecting on the quality of life of the patients and on medical costs in terms of pathology control, a promising approach for the care of various inflammatory diseases. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

JAYME, CRISTIANO CERON; REZENDE, NAYARA; FERNANDES, DANIELA S. .; PAULA, LEONARDO B. DE; DE CASTRO, BARBARA GIMENES; TAKAHASHI, LUANDRA APARECIDA U. .; TEDESCO, ANTONIO CLAUDIO. Target selectivity of cholesterol-phosphatidylcholine liposome loaded with phthalocyanine for breast cancer diagnosis and treatment by photodynamic therapy. Photodiagnosis and Photodynamic Therapy, v. 39, p. 6-pg., 2022-07-25. (18/24004-9, 21/02207-8, 18/10237-1, 15/18684-9, 13/50181-1)