Effect of elicitation by methyl jasmonate and salicylic acid on the production of secondary metabolites in suspension cell culture of Dendrobium nobile

• Grant number: 21/08418-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: December 01, 2021
• End date: November 30, 2022
• Field of knowledge: Biological Sciences - Genetics - Plant Genetics
• Principal Investigator: Mônica Rosa Bertão
• Grantee: Gabriel Mazetti Blasques
• Host Institution: Faculdade de Ciências e Letras (FCL-ASSIS). Universidade Estadual Paulista (UNESP). Campus de Assis. Assis , SP, Brazil

Abstract

Dendrobium nobile is a species of orchid native to southern China, Himalayas, Myanmar, Thailand, Laos and Viatname. In addition to economic importance in the ornamental field, this orchid has metabolites with pharmacological properties: antioxidant, anti-inflammatory, anti-diabetes, antibacterial, antiviral, anticancer, neuroprotective and antiaging. Among these metabolites, alkaloids, bibenzyl compounds, flavonoids, polysaccharides, phenanthrenes, among others, are described in the literature. Considered as a promising method for the production of secondary metabolites of pharmaceutical value, cell suspension culture has the potential to enable and increase the production of metabolites of the species in a controlled environment with the addition of elicitors in the culture. This project aims to establish a suspension cell culture of D. nobile and evaluate the activity of methyl jasmonate and salicylic acid elicitors in the production of secondary metabolites of pharmacological interest. (AU)