Role of thymic stromal lymphopoetin in modulation of Asthma-copd overlap

• Grant number: 22/01776-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: May 01, 2022
• End date: April 30, 2024
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Iolanda de Fátima Lopes Calvo Tibério
• Grantee: Eduardo Luiz da Cruz
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Both in clinical practice and in scientific research, obstructive respiratory diseases- asthma and COPD - are widely studied, with well-defined diagnostic criteria and pathophysiological mechanisms. However, in recent years, a variant of these diseases has been seen, which overlaps characteristics common to both, with clinical manifestations similar to those observed in COPD, but with a significant response to the use of bronchodilators. This clinical entity was called asthma-COPD overlap (ACO). Despite this classification, there is no consensus in the literature on the inflammatory profile, oxidative stress, pulmonary tissue remodeling, and the role of thymic stromal lymphopoietin (TLSP) in these processes, showing a lack of understanding of the pathophysiology of the disease and the mechanisms that could modulate these responses. Recent studies have shown that PSTL enhances Th2-mediated inflammation. Therefore, the hypothesis is that its inhibition of TSLP will be able to reduce inflammation, remodeling, and oxidative stress in an experimental model of ACO, functioning as a therapeutic alternative.(AU)