Long-term analysis of motor and functional outcomes of children and adolescents submitted to distinct rehabilitation protocols after hemispheric surgery (hemispherotomy) for the treatment of pharmacoresistant epilepsy

• Grant number: 22/09303-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2022
• End date: September 30, 2023
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Marcelo Volpon Santos
• Grantee: Letícia Barros dos Santos
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Epilepsy is the most common neurological disorder in children under 16 years of age, with the administration of antiepileptic drugs (AD) being the main form of treatment. However, this approach has a large portion of ineffectiveness, requiring a possible surgical intervention. Extratemporal epilepsy is the most common in children, with a higher proportion of patients having hemispheric epilepsy. For such patients, when pharmacoresistant, hemispheric pharmacoconnection surgery (hemisphere) is one of the most effective interventions in the treatment. The literature shows itself very promising in regards to functional postsurgical gains, however, there is no published work that describes the long term following, denoting the scarcity of data after long term follow-up. This work's main goal is to analyze functional capacity and its relation to the adherence to physical therapy in individuals that are compromised by pharmacoresistant hemispheric epilepsy that had done hemispherotomy after, at least, 10 years. For this, the Gross Motor Function Classification System (GMFCS), Manual Ability Classification System (MACS) and The Functional Mobility Scale (FMS) tests will be applied in the post-surgical period and analysis, in addition to the collection and data presented in the medical records. For the analysis will be applied the distribution and normality data tests, besides a statistical test fitting for evaluation and correlation among the collected data. It will adopt a significance level of 5%.