LATE CLINICAL EVALUATION OF ESOPHAGEAl MUCOSECTOMY IN THE SURGICAL TREATMENT OF ADVANCED IDIOPATHIC ACALASIA OF THE ESOPHAGUS WITH MECHANICAL SUTURE.

• Grant number: 22/08154-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2022
• End date: October 31, 2023
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Jose Luis Braga de Aquino
• Grantee: Nicole Goldenberg Levy
• Host Institution: Escola de Ciências da Vida (ECV). Pontifícia Universidade Católica de Campinas (PUC-CAMP). Campinas , SP, Brazil

Abstract

The research project in question is a prospective study that will evaluate the results of the late clinical trials of esophageal mucosectomy with conservation of the muscular tunic in patients with advanced idiopathic acalasia of the esophagus (IEA). Five patients with this condition, who present only advanced disease (Grade III/IV) will be selected, who do not have prior surgery, that the etiology is not American trypanosomiasis origin and that the patient in the study may answer a questionnaire in relation to some factors that can be predisposing factors for the etiology of idiopathic acalasia: professional occupation, mainly direct contact with potent chemicals;previous viral infections; autoimmune disease; family history of idiopathic achalasia; prolonged use of medicines mainly from the psychiatric sphere and some emotional factor related to the onset of symptomatology. Patients will be evaluated lately, between 06 months and 1 year of post operative of esophageal mucosectomy by the following parameters:1) Clinical evaluation, where the four main symptoms will be studied,Being these: dysphagia, regurgitation, retrostern pain and weight loss, and the intensity of them will be quantified from zero to 3 according to the ECKARDT and compared with the preoperative; in relation to dysphagia, this symptom will also be quantified from zero to 5 according to the criteria proposed by SAEED and also compared with the preoperative. As long-term results, patients are expected to have rescued mainly the swallowing and weight gain, providing good quality of life for patients.