SYNTHESIS AND ANTIPROLIFERATIVE EVALUATION OF A NEW INDOLIZINE LIBRARY.

• Grant number: 22/14888-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: January 01, 2023
• End date: December 31, 2023
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Giuliano Cesar Clososki
• Grantee: Maitê Bueno Giometti
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Heterocycles are structures present in the vast majority of drugs, promoting the medicinal action of these compounds. Within this class of compounds, those that present Nitrogen as the heteroatom in their structure predominate, which usually contain fused rings. Indolizine is a representative compound of this group, which has already been the subject of studies for antitumor drugs, however, research and development came up against the problem of compounds not having metabolic stability. Recently, studies carried out by the research group showed that the presence of structures with more lipophilic characteristics contribute to the activity profile. Therefore, the aims of the present project is the synthesis of a new library of indolizines with more hydrophobic structures. For this purpose, the indolizine ring will be synthesized through the Tschitschibabin reaction and functionalized at the C-2 position. Later, the compounds will be send for analysis of the antiproliferative profile, in a partner laboratory, to test activity against the tumor lines HGC-27 (Gastric cancer), CAL-27 (Oral cancer) and BT-20 (Cancer breast).