Evaluation of patients with rosacea and comorbities: eating habits, intestinal microbiota and serum cathelicidin rates

• Grant number: 22/09979-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2023
• End date: May 31, 2025
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Ediléia Bagatin
• Grantee: Bruna Manuella de Figueiredo Afonso
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Rosacea is a chronic inflammatory dermatosis. It affects men and women, aged 40 to 60 years, with lesions in the central-facial region, represented by persistent and transient erythema, edema, papules, pustules and telangiectasias. The prevalence, based on studies in developed countries, ranges from 3% to 20%, there are no national data. The pathogenesis is multifactorial, namely: genetic, immunological, vascular dysregulation, diet, environmental agents and dysbiosis in the gastrointestinal and skin microbiomes with reciprocal interference. The role of the gut microbiome has been discussed recently in stimulating the mTORC1 pathway. The association of rosacea and gastrointestinal, neurological and cardiovascular diseases is known. There is an increase in the levels of the antimicrobial peptide called cathelicidin LL-37 which, activated by kallikrein 5, has a pro-inflammatory action. This Research Project is a cross-sectional observational study on the prevalence of different types of rosacea in Brazil, intends to investigate the presence of associated comorbidities, the eating habits of individuals and understand the impact of this disease on quality of life, through the application of questionnaires. It consists of a co-participation in a master's and doctoral project from the Federal University of Rio Grande do Sul (UFRS), of a multicentric nature, involving 5 Brazilian states. Correlations with the profile of the gastrointestinal microbiome and serum cathelicidin levels will be carried out by the UFRS research center. The results may contribute to understanding the pathogenesis of rosacea, potential systemic implications and therapeutic perspectives.