Would exosome therapy be more efficient than bone grafting for bone regeneration? Systematic review and meta-analysis

• Grant number: 23/02451-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2023
• End date: July 31, 2024
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Graziela Garrido Mori Panucci
• Grantee: Virgínia Amorin Fróes de Moraes
• Host Institution: Faculdade de Medicina Dr Domingos Leonardo Ceravolo. Universidade do Oeste Paulista (UNOESTE). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil

Abstract

Tissue engineering and regenerative medicine have created possibilities for the advancement of bone regeneration, which may culminate in an ideal therapy for the treatment of bone defects. Considering their tools, in particular, the exosome, it is possible to infer its efficiency, and comparing it with existing clinical procedures is fundamental for future clinical protocols. Therefore, this research aims to analyze, through a systematic review, the effectiveness of exosome therapy for bone regeneration in comparison with established protocols and approaches. For this, the study will be conducted in accordance with the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The electronic literature search will be performed using PubMed/MEDLINE, Scopus, and Cochrane Library databases until July 2023 to answer the PICO question: "Would exosome therapy be more efficient than bone grafting for bone regeneration?" Bone regeneration will be considered the primary outcome. The dosage, route of administration, and form of extraction of exosomes, the source cells of exosomes, and the molecular mechanisms and cell types participating in tissue neoformation are included in secondary outcomes. After selecting the articles and extracting the data considering the aforementioned outcomes, the extracted data will be submitted to bias analysis and meta-analysis. It is expected to determine the best therapy to be used for bone regeneration of alveolar bone defects.