Investigating LSA - A "Legal High" Analog to LSD, with Increasing Usage and Little-known Effects.

• Grant number: 23/07651-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2023
• End date: July 31, 2024
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Principal Investigator: João Mauricio Castaldelli Maia
• Grantee: Paula de Sousa Campos Campi de Castro
• Host Institution: Centro Universitário FMABC (FMABC). Santo André , SP, Brazil

Abstract

Introduction: Psychedelics are substances highly consumed for recreational use, nevertheless the majority of these psychoactive substances are illegal and hard to obtain. Therefore, there is a demand for psychedelics legal and easier to access, these types of drugs are called '' legal highs''. LSA is one of these new psychoactive substances, this drug is searched because it is known to have an effect similar to LSD. LSA has negative effects on body functioning not completely understood by the medical field. Objectives: This study aims to do a systematic review of the literature about the effects of LSA on the body functioning.Methods: The following keywords will be searched on PubMed, Google Scholar and Web of Science database; (ergine or d-lysergic acid amide or LSA or d-lysergamide or lysergic acid amide). Original articles published in Portuguese, English, Spanish, French and italian will be included in this systematic review. Expected results: LSA is a drug with negative effects on the body functioning, with action on the organism similar to LSD and a high rate of disinformation about the consumption of this drug.