Development of functional polymeric biomaterials aimed at tissue regeneration and healing

• Grant number: 22/05316-5
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: August 01, 2023
• End date: November 30, 2026
• Field of knowledge: Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
• Principal Investigator: Daniel Souza Corrêa
• Grantee: Francisco Vieira dos Santos
• Host Institution: Embrapa Instrumentação Agropecuária. Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA). Ministério da Agricultura, Pecuária e Abastecimento (Brasil). São Carlos , SP, Brazil
• Associated research grant: 18/22214-6 - Towards a convergence of technologies: from sensing and biosensing to information visualization and machine learning for data analysis in clinical diagnosis, AP.TEM

Abstract

Chronic wounds or wounds caused by burns are considered a global health problem that damages the quality of life and raises the costs of health systems. Given this scenario, it is necessary to develop biomaterials capable of treating, regenerating and/or healing these types of wounds. In this sense, the present work aims to develop three-dimensional structures for use as multifunctional dressings that emulate the morphological, physical, chemical and biological characteristics of the skin. For this, the technique of 3D bioprinting combined with electrospinning will be used to build functional biomaterials capable of monitoring and treating skin lesions. To evaluate the physical, chemical, thermal, mechanical, rheological and biological characteristics of biomaterials, techniques such as Scanning Electron Microscopy, Atomic Force Microscopy, X-ray Computed Microtomography, X-ray Diffraction, Infrared Spectroscopy, Exploratory Calorimetry Analysis Differential (DSC) and Thermogravimetric Analysis (TGA); Mechanical Thermo-Dynamic Analysis and Rheometry, as well as tensile, controlled release, antibacterial activity, in vitro cell viability and in vivo tissue healing assays. It is hoped that this project can contribute to the scientific and technological advancement of functional biomaterials capable of monitoring and treating skin wounds in a personalized way. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ROSSI, PATRICIAF.; DOS SANTOS, FRANCISCO VIEIRA; MULKSON ALVES, ANA LAURA MARTINS; SEMENSATO, LEONARDO HENRIQUE; ROCHA OLIVEIRA, LUIS FERNANDO; DOS SANTOS, DANILO M.; BIANCHI, TIAGO DE PAULA; INADA, NATALIA M.; CAMPANA-FILHO, SERGIO PAULO; OREFICE, RODRIGO L.; et al. 3D-Printed Methacrylated Gelatin-Lignin Carbon Dot Hydrogel Combined with PLA Nanofibers for Wound Dressings. ACS APPLIED NANO MATERIALS, v. 7, n. 20, p. 13-pg., 2024-10-09. (22/05316-5, 13/07276-1, 18/22214-6)

SANTOS, FRANCISCO VIEIRA DOS; SIQUEIRA, RENATO LUIZ; RAMOS, LUCAS DE MORAIS; YOSHIOKA, SERGIO AKINOBU; BRANCIFORTI, MARCIA CRISTINA; CORREA, DANIEL SOUZA. Silk fibroin-derived electrospun materials for biomedical applications: A review. International Journal of Biological Macromolecules, v. 254, p. 34-pg., 2023-11-08. (18/22214-6, 22/05316-5, 17/26194-7)

MERCANTE, LUIZA A.; TEODORO, KELCILENE B. R.; DOS SANTOS, DANILO M.; DOS SANTOS, FRANCISCO V.; BALLESTEROS, CAMILO A. S.; JU, TIAN; WILLIAMS, GARETH R.; CORREA, DANIEL S.. Recent Progress in Stimuli-Responsive Antimicrobial Electrospun Nanofibers. POLYMERS, v. 15, n. 21, p. 26-pg., 2023-11-01. (17/10582-8, 23/13428-0, 17/20973-4, 23/01567-6, 21/11738-7, 22/05316-5, 18/22214-6)