Screening and characterization of new senolytics isolated from the Brazilian biodiversity

• Grant number: 23/07881-4
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: September 01, 2023
• End date: August 31, 2025
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Marcelo Alves da Silva Mori
• Grantee: Josiane Érica Miyamoto
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 21/08354-2 - The interplay between the immune system and metabolism as a key determinant of the aging process, AP.TEM

Abstract

The use of drugs that decrease the senescence cell burden is currently among the most promising therapeutic venues to treat age-associated diseases and reverse aging. We will test the role of senotherapeutics using a translational approach with the focus on developing new strategies to improve immunity and counteract metabolic dysfunction and reproductive senescence that are accompanied by aging. We will use a combination of unbiased and hypothesis-oriented strategies to come up with new senotherapeutic compounds among molecules isolated from the Brazilian biodiversity. We will screen these new senotherapeutics using a combination of in silico and in vitro approaches and validate their role in vivo using mouse models. (AU)