The Association between D-dimer Levels and Community-Acquired Pneumonia Outcomes

• Grant number: 23/06897-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2023
• End date: October 31, 2024
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Júlio César Garcia de Alencar
• Grantee: Nícolas Corrêa Stefani
• Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil

Abstract

The overall incidence of hospitalization for Community-Acquired Pneumonia (CAP) is high and associated with significant morbidity and mortality. Thrombotic complications, including venous, arterial, and possibly microvascular, occur in patients hospitalized for various CAP etiologies. In addition, adverse outcomes in patients with pneumonia may be mediated by inflammatory and thrombotic processes, which lead to respiratory, cardiac, and other organ dysfunction.This prospective cohort study, which will be carried out in the ward of the Hospital das Clínicas de Bauru, Bauru, São Paulo, intends to evaluate the association between serum levels of D-dimer on admission and prognosis (in-hospital mortality, dead in 28 days, need for Intensive Care Unit and orotracheal intubation) of patients over 18 years of age hospitalized for less than 72 hours with a diagnosis of pneumonia.We hope to recruit at least 200 patients to demonstrate that patients with D-Dimer > 500 ng/mL are 10 times more likely to have in-hospital mortality than patients with D-Dimer considered negative.This study hopes not only to evaluate a prognostic marker, but also to contribute scientifically to knowledge about coagulopathy in patients with pneumonia.