Interactions of selected ligands and biomolecules with medicinal interest in the Alzheimer disease

• Grant number: 23/11984-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2023
• End date: October 31, 2025
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Ana Maria da Costa Ferreira
• Grantee: Wictor Gabriel da Silva Leal
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 13/07937-8 - Redoxome - Redox Processes in Biomedicine, AP.CEPID

Abstract

In these studies we intend to go further in our investigations on the biological activity of oxindolimines and its hydrazone derivatives as antitumor agents and inhibitors of amyloid peptides, implicated in Alzheimer disease (AD). New derivatives will be designed and obtained, based on isatin as precursor. The physico-chemical characterization of these compounds, as well as their interactions with crucial molecules as DNA, protein HSA and amyloid peptides, will be provided by diverse methodologies, including mostly UV/Vis, CD, fluorescence and EPR spectroscopies. Our aim is elucidating their possible modes of action in biological medium, modulated by metal ions copper, zinc or iron, causing oxidative damage and aggregation.