Heparin and heparinoids in vascular biology

• Grant number: 23/13906-0
• Support Opportunities: Scholarships in Brazil - Program to Stimulate Scientific Vocations
• Start date: February 05, 2024
• End date: March 24, 2024
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Principal Investigator: Helena Bonciani Nader
• Grantee: Bianca Alves de Sousa
• Host Institution: Instituto Nacional de Farmacologia (INFAR). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

The present project aims to better understand the role played by syndecan-4 invascular biology involving cell signaling pathways related to migration processes. cellproliferation and adhesion. The behavior of wild-type endothelial cells and endothelialcells that do not express syndecan-4 and that overexpress this proteoglycan whenfaced with stimuli using different preparations of heparin and heparinoids will beevaluated by: 1) measurements of cell proliferation, adhesion and migration; 2)morphological characteristics, involving the analysis of the arrangement of thecytoskeleton (actin filaments), as well as the projections (filopodia, lamelopodia andmicrospicules) and the arrangement (spreading) of these cells. (AU)