USE OF CARBOXYMETHYLCELLULOSE AND VEGETABLE POLYSACCHARIDE FOR THE PREVENTION OF ADHESION FORMATION IN MEDIASTINAL AFTER THORACOTOMY: EXPERIMENTAL STUDY IN RATS

• Grant number: 23/09428-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2023
• End date: October 31, 2024
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Lindemberg da Mota Silveira Filho
• Grantee: Brenda Lee Oliveira
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The formation of post-operative retrosternal and intrapericardial adhesions in cardiac surgery poses a threat for future re-interventions, increasing re-operations surgery time and raising morbidity and mortality rates.Many agents have been studied to prevent the formation of adhesions. Some of them have carboxymethylcellulose in their composition, which acts as a physical barrier and have shown to be efficient.Adhesion® (DMC, São Carlos, Brasil), is a commercial available product, formed by the combination of carboxymethylcellulose with vegetable polysaccharide. It has scar remodeling action, and helps to reduce the formation of adhesions in several surgical areas.To contribute to the study of non-adherent agents in cardiac surgery, we will use Adhesion® in rats, which will be reoperated and restudied after 8 weeks. Adhesions will be scored from 0 to 4, by "blind" evaluators, through photos taken before heart harvesting. Also, histological slides will be performed, stained with hematoxylin and eosin for evaluation. We will analyze whether there is effectiveness in reducing the formation of adhesions with the use of the drug, and if a specific formulation may be related to better results.