Encapsulation of tetrahydro-beta-carboline derivatives in aqueous and partially aqueous medium in beta-cyclodextrin to obtain chemiluminescent sensors.

• Grant number: 23/06750-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: January 01, 2024
• End date: December 31, 2024
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Joséf Wilhelm Baader
• Grantee: Daniel Barone Menezes
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The use of cyclodextrins has been shown to be a good alternative in situations where it is necessary to increase the solubility of a hydrophobic compound in a system with a polar solvent, given its high polarity in the outer region and its central hydrophobic cavity. In other words, the aim is to improve the efficiency of the activity of a particular molecule through its encapsulation (or the formation of nanoparticles).Like many organic compounds, ²-carbolines are mostly hydrophobic. Therefore, the combination of these two classes of compounds, producing cyclodextrin e ²-carbolines complexes (²-CDTs), is of great advantage for applications in light-emitting based systems - such as the peroxyoxalate reaction - aiming at both more accurate control in the release of ²-carbolines, and thus prolonging the chemiluminescent effect of the process, as well as the increased probability of effective interactions between reagents of different polarities. The comparison of absorption and fluorescence spectra is highly recommended for the characterization of the efficiency of encapsulation and nanoparticle formation.Concurrently, the complexation of heavy metals with different ²-CDTs can prove to be of great importance in identifying systems contaminated with these cations. Therefore, there is also interest in applying ²-CDTs as sensors of harmful contaminants to the environment. Therefore, in this research project, the encapsulation and formation of cyclodextrin nanoparticles with ²-carbolines, as well as the formation of metal complexes of cyclodextrin with different heavy metal cations, will be studied. Subsequently, the peroxyoxalate reaction will be studied in the presence of cyclodextrin, using ²-carbolines as activators, as well as peroxyoxalate systems with encapsulated ²-carboline derivatives and nanoparticles ²-CDT, all of them in the absence and presence of heavy metal cations. These results may contribute to the development a diagnostic method for these contaminants.